Antibacterial and Antibiofilm Activity of 8-Hydroxyquinoline Derivatives Against Mycobacterium and Staphylococcus Species.

ABSTRACT: A series of 8-alkoxyquinoline derivatives (QD-1-12) were designed and synthesized on the basis of analogues of 8-hydroxyquinoline (8-HQ) (HQ 1-4). The compounds were evaluated for biofilm inhibition against Mycobacterium smegmatis and Staphylococcus aureus, including antibacterial activity against Mycobacterium tuberculosis, M. smegmatis and S. aureus. Cytotoxicity was evaluated against human monocyte (U937) and African green monkey kidney (Vero) cell lines. The 8-O-prenyl derivative (QD-12) showed a minimum inhibitory concentration (MIC) of 12.5 µM, indicating an approximate 8-fold increased selectivity for the biofilm phenotype and an increased inhibitory activity against methicillin-resistant S. aureus (MRSA) by up to 2-fold. 5,7-Dichloro-8-hydroxy-2-methylquinoline (HQ-2) showed the hi

SUBMITTER: Lall N 

PROVIDER: S-EPMC12716008 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature