Exploring the Antiproliferative Activity of Flavolignans From the Leaves of Casearia arborea (Salicaceae).

ABSTRACT: The Casearia genus (Salicaceae) is well known as a source of natural antitumor prototypes, as described for clerodane diterpenes. In this way, the dichloromethane phase from leaves of Casearia arborea was phytochemically evaluated in liquid chromatography coupled to high-resolution mass spectrometry, furnishing flavonoid, flavolignan, and phenylpropanoid derivatives, and apocarotenoid terpenoids according to Global Natural Products Social Molecular Networking (GNPS) dereplication. The flavolignans were chemically monitored by liquid chromatography using a UV-Vis detector and purified by a semi-preparative liquid chromatographic system, furnishing tricin, tricin-4″-O-(threo-guaiacylglyceryl) ether (salcolin A), and tricin-4″-O-(erythro-guaiacylglyceryl) ether (salcolin B). Additionally, it

SUBMITTER: Santos AL 

PROVIDER: S-EPMC12716014 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature