DES-Promoted Synthesis of 3,4-Dihydropyrimidinones and Their Antidiabetic and Antioxidant Evaluation Supported With Computational Studies.

ABSTRACT: A series of 3,4-dihydropyrimidinone (DHPM) derivatives was synthesized using a green deep eutectic solvent (DES) system composed of ZnCl₂ and urea, which acted simultaneously as solvent, catalyst, and in situ substrate (urea). The synthesized compounds were evaluated for their antidiabetic potential via α-glucosidase and α-amylase inhibition assays, as well as for antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), and nitric oxide (NO) scavenging assays. Among the series, compound 3f exhibited superior inhibitory activity against α-glucosidase (IC₅₀ = 35.25 µM) and α-amylase (IC₅₀ = 38.61 µM), being ∼2.3- and ∼2.6-fold more potent, respectively, than the standard drug acarbose. In antioxidant evaluatio

SUBMITTER: Kumar G 

PROVIDER: S-EPMC12716021 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature