Cerebellar Functional Alterations during Executive Functioning are Associated with General Psychopathology in a Cross-Diagnostic Sample.

ABSTRACT:

Background

Accumulating evidence points to the cerebellum's role in executive functioning (EF) and transdiagnostic psychopathology. A general psychopathology 'p-factor,' capturing shared variation across mental disorders, has been associated with EF deficits and structural alterations within the posterior cerebellum. One hypothesis is that the cerebellum contributes to general psychopathology because of its role in executive dysfunctions.

Methods

To test this hypothesis, we employed functional magnetic resonance imaging (fMRI) data from the UCLA Consortium for Neuropsychiatric Phenomics study including 257 adults (aged 21-50) who met diagnostic criteria for schizophrenia, bipolar, or attention deficit-hyperactivity disorders or were healthy controls. We examined relations be

SUBMITTER: Romer AL 

PROVIDER: S-EPMC12716028 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature