Epidemiology of bacterial biofilms on polyps and normal tissues in a screening colonoscopy cohort.

ABSTRACT:

Background

Invasive bacterial biofilms are implicated in colorectal cancer. However, their prevalence on histologically normal tissues and polyps is not well established, and risk factors of biofilms have not been previously investigated. Here we evaluated potential procedural and demographic risk factors associated with biofilm status using a cross-sectional observational cohort.

Methods

Histologically normal colonic biopsies from 2,051 individuals undergoing screening colonoscopy were evaluated for biofilm status using fluorescence in situ hybridization with oligonucleotide probes targeting bacterial 16S rRNA. Polyp tissues from 21 individuals were also examined. Procedural, demographic, and lifestyle predictors of bacterial scores were evaluated using multivariable propor

SUBMITTER: Drewes JL 

PROVIDER: S-EPMC12716056 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature