Decoding the role of the arginine dihydrolase pathway in shaping human gut community assembly and health-relevant metabolites.

ABSTRACT: The arginine dihydrolase pathway (arc operon) provides a metabolic niche by transforming arginine into metabolic byproducts. We investigate the role of the arc operon in probiotic Escherichia coli Nissle 1917 on human gut community assembly and health-relevant metabolite profiles. By stabilizing environmental pH, the arc operon reduces variability in community composition in response to pH perturbations and frequently enhances butyrate production in synthetic communities. We use a tailored machine learning model for microbiomes to predict community assembly in response to variation in initial media pH and arc operon activity. This model uncovers the pH- and arc operon-dependent interactions shaping community assembly. Human gut species display altered colonization dynamics in response to t

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12716064 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature