Mapping drug distribution using CT imaging following direct tissue injection in ex vivo liver: informing clinical implementation.

ABSTRACT:

Purpose

Direct intratumoral injection of therapeutic drugs can minimize total dose and adverse effects compared to systemic administration. Leakage from the injection site may cause variable drug distribution and efficacy, and off-target toxicity. This study aimed to evaluate the co-injection of an iodinated contrast agent with an imageable surrogate drug (fluorescent albumin) to estimate spatial drug distribution.

Methods

Fluorescent albumin and iodixanol were injected (1, 2, or 4 mL at 1 mL/min) into ex vivo bovine liver. Distribution of iodine on CT was compared to fluorescent albumin on fluorescence microscopy, including comparison of distribution volume in liver as a function of injected volume. Physical properties (hydrodynamic diameter, zeta potential) of both iodixan

SUBMITTER: Morhard R 

PROVIDER: S-EPMC12716157 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature