A multifunctional theranostic ultrasound platform for remote magnetogenetics and expanded blood-brain barrier opening.

ABSTRACT:

Introduction

Brain stimulation techniques are critical for unraveling the innerworkings of complex neuronal pathways governing both normal physiological function and pathologic states in neurological disorders. Focused ultrasound (FUS) is an emerging technique poised to significantly alter central nervous system (CNS) drug delivery and neuroscience research through non-invasive means. Magnetogenetics is a brain stimulation technique which may benefit from FUS technology in that alternating magnetic fields (AMF), like FUS, can pass through the skull without requiring surgery.

Methodology

Magnetogenetics involves the deposition of superparamagnetic iron-oxide nanoparticles (SPIONs) and overexpression of thermoreceptor transmembrane proteins (e.g. TRPV1 and TRPA1) in the brain.

SUBMITTER: Batts AJ 

PROVIDER: S-EPMC12716165 | biostudies-literature | 2025 Nov-Dec

REPOSITORIES: biostudies-literature