Genetics of glucose homeostasis in pregnancy and postpartum.

ABSTRACT:

Aims/hypothesis

Pregnancy is accompanied by maternal metabolic adaptations to ensure fetal growth and development, including insulin resistance, which occurs primarily during the second and third trimesters of pregnancy, and a decrease in fasting blood sugar levels over the course of pregnancy. Glucose-related traits are regulated by genetic and environmental factors and modulated by physiological variations throughout the life course. We addressed the hypothesis that there are both overlaps and differences between genetic variants associated with glycaemia-related traits during and outside of pregnancy.

Methods

Genome-wide SNP data were used to identify genetic variations associated with glycaemia-related traits measured during an OGTT performed at ~28 weeks' gestation in 8

SUBMITTER: Lowe WL 

PROVIDER: S-EPMC12716172 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature