Amphiphile-Assisted Synthesis of Ruthenium Nanoparticles for Controlled Release and Enhanced Antibacterial Activity.

ABSTRACT: A novel procedure for preparing Ruthenium nanoparticles (RuNPs) based on low-molecular-weight amphiphilic molecules and Ru(III) complexes as antibacterial agents with controlled release properties has been developed. Two hydrophobic Ru(III) complexes, Ru-TOA and Ru-Benza, analogs to the NAMI-A prodrug, are encapsulated within the core of the micelles formed through the self-assembly of these amphiphiles. The self-assembly of amphiphile I, which contains a double polar head, results in highly water-stable and monodispersed RuNPs incorporating both hydrophobic Ru complexes. These RuNPs exhibit hydrodynamic sizes ranging from 26.7 to 104.2 nm for NPs derived from Ru-TOA complex, and ≈10 nm for those derived from Ru-Benza. Compared to Ru(III) complexes, these RuNPs offer several advantages, in

SUBMITTER: Gimeno-Ferrero R 

PROVIDER: S-EPMC12716183 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature