Guided Bone Regeneration Membrane Materials Loaded with Chimeric Nanovesicles Promote Early Bone Defect Regeneration.

ABSTRACT: Early bone defect regeneration remains a major clinical challenge owing to a compromised osteogenic microenvironment characterized by insufficient mineralization and immature collagen deposition, which severely impede mechanical stability. Although conventional guided bone regeneration (GBR) membranes provide passive barrier functions, their lack of dynamic immune response regulation often leads to delayed ossification. To address this critical gap, a plasma-treated polycaprolactone (PT-PCL) electrospun nanofiber membrane functionalized with ultrasound sequentially extruded stromal vascular fraction chimeric vesicles (USE-SCNVs) is developed. The ultrasound-sequential extrusion approach requires less equipment, is faster, and holds greater potential for clinical application than traditiona

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12716199 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature