Zwitterionic Photocurable Resin for High-Resolution 3D Printing of Ultralow-Fouling Microstructures.

ABSTRACT: High-resolution 3D printing technologies are enabling a new generation of microstructured materials for applications where biocompatibility is critical. However, most conventional 3D-printable resins yield materials that exhibit trade-offs between antifouling properties and mechanical robustness, limiting their applicability in living systems. In nature, zwitterionic surface groups form tightly bound hydration layers that act as effective barriers against protein and cell attachment. Inspired by this strategy, a zwitterionic acrylamide-based photoresist-carboxybetaine di-methacrylamide (CBDA)-is developed for projection-based vat photopolymerization, enabling the fabrication of complex microarchitectures with exceptional antifouling properties. The bifunctional monomer allows the formation

SUBMITTER: Wang K 

PROVIDER: S-EPMC12716207 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature