Synergistic Combination of Tamoxifen-Tetraphenylethylene Co-Assembled Micelles and Orlistat-Induced Lipid Droplet Inhibition to Overcome Tamoxifen Resistance.

ABSTRACT: Nanostructured supramolecular materials enable the precise control of biological interactions by tuning structural features such as size, shape, and surface charge, allowing targeted cellular uptake, optimized biodistribution, and enhance therapeutic efficacy. Despite its clinical success, tamoxifen (TMX) therapy faces challenges, such as drug resistance development; a key resistance mechanism involves intracellular lipid alterations. Lipid droplets (LD) play a crucial role in cancer progression and resistance to therapy. However, the direct suppression of LD formation as a synergistic adjunct to enhance TMX delivery remains underexplored. In this study, a supramolecular micelle platform based on amphiphilic tetraphenylethylene derivatives are presented with tunable oligoethylene glycol (O

SUBMITTER: Park JY 

PROVIDER: S-EPMC12716221 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature