Long-Term Stable Neural Interfaces with Nanoporous Graphene Electrodes and Hybrid Polyimide-Aluminium Oxide Encapsulation.

ABSTRACT: Graphene-based thin film technology holds great promise for next-generation neural interfaces due to graphene´s electrical, electrochemical, and mechanical properties. However, the long-term reliability of this technology remains a challenge, primarily due to the instability of thin-film encapsulation in physiological environments. While standard ceramic encapsulation is robust, it is not compatible with the miniaturization required for minimally invasive implants. This study demonstrates the successful integration of a hybrid encapsulation strategy, combining polyimide with atomic layer deposited (ALD) Al₂O₃, with nanoporous reduced graphene oxide (rGO) microelectrodes, resulting in chronically stable graphene-based neural interfaces. The encapsulation robustness is

SUBMITTER: Katirtsidis GA 

PROVIDER: S-EPMC12716225 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature