Ambient air pollution exposure and lung cancer risk in a large prospective U.S. cohort.

ABSTRACT:

Background and aim

Outdoor air pollution, including fine particulate matter (PM_2.5), is an established cause of lung cancer; however, few studies have evaluated associations by histologic subtype.

Methods

We estimated outdoor PM_2.5 and nitrogen dioxide (NO₂) concentrations at the residential enrollment (1995-1996) address for 486,101 participants of the NIH-AARP Diet and Health Study, a cohort located in 6 states and 2 metropolitan areas. We used annual estimates from a national spatiotemporal model to assess concentrations for a 5-year pre-enrollment period (1990-1994). We used Cox regression to estimate hazard ratios and 95 % confidence intervals (HR [CI]) for associations with incident lung cancer overall and by histologic subtype per IQR

SUBMITTER: Fisher JA 

PROVIDER: S-EPMC12716236 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature