Differential glymphatic dysfunction and memory correlation in temporal lobe epilepsy subtypes.

ABSTRACT:

Objective

This study aims to evaluate the glymphatic system (GS) in different temporal lobe epilepsy (TLE) subtypes using diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) and to explore its correlation with clinical factors and memory performance.

Methods

The study encompassed 112 TLE patients with hippocampal sclerosis (TLE-HS), 73 TLE patients with no lesions on magnetic resonance imaging (TLE-NL), and 55 healthy controls. The DTI-ALPS index was calculated based on 3.0T diffusion tensor image sequences, and the memory performance was assessed using the Wechsler Memory Scale-Revised. The DTI-ALPS index was compared among the three groups, and its relationships with clinical characteristics and memory performance were explored.

Results

TLE-HS

SUBMITTER: Chen R 

PROVIDER: S-EPMC12716296 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature