Nonseizure symptoms and broader seizure impacts in patients with Dravet syndrome and Lennox-Gastaut syndrome in clinical practice settings: Results from a multinational survey.

ABSTRACT:

Objective

To assess the burden of Dravet syndrome (DS) and Lennox-Gastaut syndrome (LGS), including managing seizure and nonseizure symptoms, on patients and caregivers.

Methods

Data were drawn from the Adelphi Real World DS and LGS Disease Specific Programme™, a cross-sectional survey in Asia (China, Japan), Europe (France, Germany, Italy, Spain, United Kingdom), and the United States of America between July 2022 and August 2023. Neurologists/pediatric neurologists reported demographics, clinical characteristics, and nonseizure symptoms for up to 10 consecutively consulting patients. Caregivers provided data on patient nonseizure symptoms, quality of life (QoL), satisfaction with treatment, and caregiver burden. Analyses were descriptive.

Results

Physicians (n = 259)

SUBMITTER: Shah D 

PROVIDER: S-EPMC12716298 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature