Autoimmune and paraneoplastic encephalitis-associated neuronal autoantibodies with serial EEG in adults with unexplained new-onset seizures or worsening epilepsy.

ABSTRACT:

Objective

Unexplained seizures or worsening epilepsy in adult patients may be associated with specific neuronal or onconeuronal antibodies. We propose that comprehensive antibody testing is beneficial for adults with new-onset seizures or aggravated epilepsy without a predetermined etiology. Additionally, a combination of serial electroencephalography (EEG) may enhance clinical management.

Methods

Adult patients with new-onset seizures or worsening of existing epilepsy of an unknown cause who were admitted for comprehensive evaluation and management (including cerebrospinal fluid study, brain MRI, and EEG) were retrospectively and consecutively enrolled. Clinical and laboratory data were also collected. Antibody prevalence in epilepsy score (APE) and antibody prevalence in e

SUBMITTER: Cheng CE 

PROVIDER: S-EPMC12716301 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature