Using Cenobamate for managing idiopathic generalized epilepsy: A single-center experience and systematic literature review.

ABSTRACT:

Objective

To evaluate the single-center experience of Cenobamate's (CNB) off-label use in adults with idiopathic generalized epilepsy (IGE).

Methods

We conducted a retrospective review of electronic health records within a large healthcare system to identify IGE patients prescribed CNB. Extensive clinical and medication-related data were extracted, including monthly seizure frequency at baseline, 3, 6, and 12 months, and at last follow-up. We used CNB retention, a marker of its potential effectiveness and tolerability, for 12 months as the primary outcome of interest. Statistical analysis, including Kaplan-Meier survival analysis, was performed to estimate CNB retention over time. We also performed a systematic literature review investigating seizure reduction after CNB use

SUBMITTER: Woodrich N 

PROVIDER: S-EPMC12716304 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature