The effect of cortical and subcortical parcel volumes on postictal generalized EEG suppression.

ABSTRACT:

Objective

Alterations to brain structures and networks involved in central autonomic and respiratory control are possible biomarkers of SUDEP, but were mainly demonstrated in people at high risk. Postictal generalized EEG suppression (PGES) has been recorded in every case of near or confirmed SUDEP. The structural alterations underpinning PGES are not known.

Methods

This retrospective study included the brain MRIs of 100 patients with focal and generalized epilepsy who had experienced at least one generalized tonic-clonic seizure (GTCS) documented through long-term video-EEG monitoring, with PGES defined as postictal EEG activity below 10 microvolts lasting at least 20 s. Brain MRIs were parcellated into cortical and subcortical volumes, with further parcellation of thalamic

SUBMITTER: Bascarevic V 

PROVIDER: S-EPMC12716305 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature