Defining the role of systemic autoimmune markers in adult epilepsy: A focus on autoimmune-associated epilepsy.

ABSTRACT:

Objective

Autoimmune mechanisms are a recognized cause of adult epilepsy, with immunotherapy offering etiology-specific treatment. Autoimmune-associated epilepsy is an emerging clinical entity, for which early diagnosis remains challenging and largely depends on neuronal antibody testing. This study investigates the utility of serum systemic autoantibodies as surrogate markers for positive neuronal antibodies and their potential in predicting epilepsy outcomes.

Methods

We retrospectively enrolled adult epilepsy patients, excluding those with prior autoimmune diseases. All patients had baseline laboratory data, including ESR, ANA, and anti-ENA. Further immunological evaluations included serum or CSF studies for systemic or neuronal autoantibodies. We compared the prevalence o

SUBMITTER: Lin IT 

PROVIDER: S-EPMC12716306 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature