PH-responsive regulation of multiphase coacervate wetting <i>via</i> phase selective enrichment of fatty acids.

ABSTRACT: Biomolecular condensates with multiphasic architectures organize specific biomolecular processes in different compartments and dynamically reconfigure their structure to regulate their biological functions. Here, we employ multiphase coacervates as model condensates to illustrate pH-responsive dynamic reconfiguration of multiphase wetting interactions mediated by phase selective enrichment of fatty acids. We noted that unsaturated fatty acids such as linolenic acid (LA) can enrich within specific coacervates, via spontaneous substitution of like charged coacervate components, to drastically alter coacervate properties such as viscosity and surface tension. By selectively enriching fatty acids within the outer phase of a multiphase coacervate, the changes in coacervate properties wer

SUBMITTER: Sharma P 

PROVIDER: S-EPMC12716314 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature