Tumor Mutations in Minority Populations Versus Non-Hispanic Whites Across Tumor Types.

ABSTRACT:

Purpose

To investigate tumor mutation variations across different racial/ethnic groups to better understand implications for targeted cancer therapies.

Methods

A retrospective analysis of 5,045 patients at University of New Mexico Comprehensive Cancer Center who underwent tumor genetic testing between January 2015 and April 2022 was conducted. Data were standardized from internal genetic tests, FoundationOne, and Guardant next-generation sequencing panels. Chi-square tests, one-way analysis of variance, and negative binomial regression estimated differences in mutation rates across race/ethnicity, adjusting for cancer type, age, testing year, and number of genes screened. Primary outcomes included tumor mutation rates and their variation across racial/ethnic groups. Specific

SUBMITTER: Coy J 

PROVIDER: S-EPMC12716363 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature