Photoredox-controlled chemo-divergent, regio-, and stereoselective difunctionalization of olefins via switchable SO₂ reintegration.

ABSTRACT: While radical difunctionalization offers substantial potential for molecular diversification, existing methodologies predominantly focus on styrenes and activated alkenes, leaving fundamental light olefins (e.g., ethylene and propylene) largely unexplored. Moreover, achieving stereoselective transformations of light olefins remains a formidable challenge. Here, we present a visible-light-mediated photoredox-catalyzed chemo-divergent and regioselective radical difluoromethylation/polyfluoroarylsulfonylation and difluoromethylation/polyfluoroarylation of structurally diverse alkenes through switchable sulfur dioxide reintegration. The method demonstrates broad applicability across styrenes, unactivated alkenes, and gaseous ethylene/propylene substrates. The photocatalyst functions as a switc

SUBMITTER: Xia J 

PROVIDER: S-EPMC12716424 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature