Association between first anticoagulant prescription and embolic and hemorrhagic events among older adults with atrial fibrillation.

ABSTRACT:

Background

The impact of first prescription of oral anticoagulation on ischemic stroke and major bleeding events among Medicare beneficiaries with atrial fibrillation (AF) is not known.

Methods

A retrospective, observational, cohort study was performed based on a 5% sample of United States fee-for-service Medicare beneficiaries aged ≥66 years who developed AF from 2007 to 2020. The principal exposure was first prescription of an oral anticoagulant. The primary effectiveness end point was ischemic stroke (including cerebral or retinal ischemic stroke [central retinal artery occlusion]). The primary safety end point was major bleeding. To reduce the impact of selection bias and immortal time bias, unadjusted and adjusted hazard ratios (HRs) and rate differences were computed i

SUBMITTER: Lusk JB 

PROVIDER: S-EPMC12716431 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature