Retinal Impairments in Mice Lacking Both Nxnl1 and Nxnl2 Genes.

ABSTRACT:

Purpose

The protein products of the nucleoredoxin-like 1 (Nxnl1) gene have been proposed for their potential therapeutic benefit in retinitis pigmentosa (RP). Nxnl1 encodes two isoforms: rod-derived viability factor (RdCVF), which supports cone photoreceptor survival, and RdCVFL, which mitigates oxidative stress. Similarly, Nxnl2, a paralog of Nxnl1, encodes RdCVF2 and RdCVF2L, which also have photoreceptor protective properties. This study aimed to investigate whether the simultaneous disruption of Nxnl1 and Nxnl2 results in a more severe retinal phenotype on photoreceptor status compared to the disruption of either gene individually.

Methods

Double Nxnl1-/-Nxnl2-/- mice were generated, and their retinal phenotype was compared to Nxnl1-/-, Nxnl2-/-, and Nxnl1+/+Nxnl2+/+ mic

SUBMITTER: Li Z 

PROVIDER: S-EPMC12716451 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature