Associations of accelerated biological aging with intraoperative hypotension in major surgery: a multicenter cohort study of 116,996 patients.

ABSTRACT:

Background

Intraoperative hypotension (IOH) is a prevalent hemodynamic complication associated with adverse postoperative outcomes. Identifying patients at high risk for IOH remains a challenge. Accelerated biological aging, reflecting cumulative physiological decline, may heighten susceptibility to hypotensive events by impairing cardiovascular homeostasis and autonomic regulation, making it a potent yet underutilized predictor in perioperative medicine.

Materials and methods

This multicenter retrospective cohort study analyzed 116,996 adults undergoing major cardiac and non-cardiac surgery across three tertiary academic medical centers in Eastern China. Accelerated biological aging was measured using Phenotypic Age Acceleration (PhenoAgeAccel). Outcomes included incidence

SUBMITTER: Jiang J 

PROVIDER: S-EPMC12716467 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature