Photosensitive composite nanoparticles adsorbing p-sh<i>BLM</i> for the synergistic therapy of neuroblastoma.

ABSTRACT: Photodynamic therapy (PDT) represents a promising noninvasive modality for the selective targeting of tumors. However, its clinical utility is often constrained by the aggregation-induced quenching of photosensitizers and suboptimal reactive oxygen species (ROS) generation. In contrast, gene therapy has exhibited potent antitumor efficacy through the specific silencing of oncogenic targets. In this study, we developed a cationic photosensitizer-based nanocarrier, PEI-PEG-PpIX, designed to deliver the shRNA-BLM plasmid (p-shBLM). The PEI-PEG-PpIX/p-shBLM complex demonstrated a threefold increase in ROS production compared to free PpIX, along with a 57.5% enhancement in transfection efficiency. When this method was combined with photodynamic therapy for the treatment of

SUBMITTER: Luo X 

PROVIDER: S-EPMC12716475 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature