Abnormal vortex formation by 4D flow MRI as a marker for aortic valve replacement in moderate aortic stenosis: an exploratory study.

ABSTRACT:

Background

Predicting progression to aortic valve replacement (AVR) in moderate aortic stenosis (AS) is challenging. This study explored whether haemodynamic parameters from four-dimensional flow MRI (4D flow MRI) are associated with the potential progression to AVR.

Methods

15 patients with moderate AS underwent baseline 4D flow MRI and echocardiography, with repeat echocardiography within 2 years. Patients were categorised into AVR (n=8) or no-AVR (n=7) groups based on whether they underwent AVR during follow-up.

Results

AVR occurred a mean of 396±156 days after baseline. The AVR group had higher follow-up peak velocity (p=0.001), mean pressure gradient (p=0.022) and smaller valve area (p=0.004). Baseline peak vortex volume was greater in the AVR group (p=0.009) and

SUBMITTER: Park S 

PROVIDER: S-EPMC12716593 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature