The feasibility of salivary melatonin in assessing perioperative circadian rhythm in surgical patients: study protocol for a multicentre prospective study in China.

ABSTRACT:

Introduction

Circadian rhythm disturbance is associated with neurologic, metabolic, cardiovascular and immune disorders. As the most reliable biomarker of endogenous circadian rhythms, melatonin regulates the sleep-wake cycle and promotes sleep. Studies have demonstrated that saliva and plasma melatonin levels show strong correlations in non-surgical populations. However, the relationship between salivary and plasma melatonin measurements in patients undergoing surgery is unknown. This study will analyse the correlation between the peak concentrations of salivary and blood melatonin in perioperative patients.

Methods and analysis

In this prospective study, 102 patients scheduled for thoracic or neurosurgical procedures are being enrolled. The primary outcome of this study is

SUBMITTER: Chen B 

PROVIDER: S-EPMC12716594 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature