FLUid management and InDividualized resuscitation in Sepsis (FLUIDS)-A Study protocol for a single-centre, open-label, randomized clinical trial.

ABSTRACT:

Introduction

Early septic shock results from complex hemodynamic disturbances, including vasodilation, capillary leakage, and hypovolemia, requiring timely resuscitation to prevent organ failure. Initial fluid administration in the emergency department (ED) varies widely, influenced by clinician experience, patient comorbidities, and infection source. Fluid therapy is frequently not tailored to individual patient responsiveness and tolerance, highlighting the importance of personalized resuscitation strategies.

Objective

This study evaluates the effectiveness of a personalized hemodynamic resuscitation strategy during the initial management of sepsis in the ED, using continuous non-invasive stroke volume index (SVI) measurements to guide intravenous (IV) fluid therapy and ea

SUBMITTER: Ter Horst S 

PROVIDER: S-EPMC12716701 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature