Dose-finding for dobutamine during transitional circulation in the very preterm infant: The study protocol.

ABSTRACT:

Background

Hemodynamic insufficiency occurs when tissue oxygen delivery fails to meet demand. Preterm infants are vulnerable to early circulatory failure after birth, impacting mortality and morbidity. Mean arterial pressure is not a reliable indicator of systemic blood flow. Low superior vena cava (SVC) flow, independent of fetal shunts, has been proposed as a robust biomarker of circulatory impairment in this population. Dobutamine, a selective β1 agonist with minimal effect on systemic vascular resistances, is considered the treatment of choice for this condition. However, information about its optimal dosing, efficacy, safety, and pharmacokinetic/pharmacodynamic (PK/PD) profile in preterm infants is limited.

Methods

A multicenter, low-intervention, dose-finding trial wil

SUBMITTER: Sanchez-Holgado M 

PROVIDER: S-EPMC12716709 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature