Lysergic acid diethylamide-derived excitatory/inhibitory ratio change enhances global synchrony in functional brain dynamics.

ABSTRACT: Lysergic acid diethylamide (LSD) has shown remarkable potential in modulating brain functional organization and dynamics. However, the exact mechanisms underlying its effects remain unclear. In this study, we employed a data-driven approach to analyze recurrent functional connectivity patterns in resting-state fMRI data and developed a parameterized feedback inhibition model to characterize excitatory/inhibitory (E/I) balance. The findings demonstrate that LSD enhances global brain synchrony and dynamic complexity. This enhanced synchrony likely stems from LSD's preferential stabilization of a globally synchronized yet functionally non-modular brain state - a pattern showing higher occurrence probability and acts as an "attractor" that recruits transitions from cognitive control networks.

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12716743 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature