Potential association of certain microRNA gene polymorphisms with recurrent pregnancy loss susceptibility in Saudi women.

ABSTRACT: MicroRNA (miRNA) polymorphisms are increasingly recognized as important regulators of reproductive outcomes, but their role in recurrent pregnancy loss (RPL) is still unexplored in specific populations. This case control study investigated six miRNA polymorphisms (miR-10-A > T, miR-125-G > A, miR-146a-C > G, miR-149-T > C, miR-323b-C > T, miR-499-A > G) in 50 Saudi women with idiopathic (≥ 2 losses) and 50 matched controls (≥ 1 live birth, no loss history) using PCR Sanger sequencing. Significant associations were found for heterozygous genotypes of miR-146a-C > G (OR=2.29, 95% Cl:1.02-5.18, *p* = 0.046) and miR-149-T > C (OR=2.67, 95% Cl:1.08-6.61, *p* = 0.034) with higher prevalence in RPL patients versus controls, while other polymorphisms showed no significant association (*p* > 0.05).

SUBMITTER: Rabaa A 

PROVIDER: S-EPMC12716758 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature