Naringenin attenuates liver injury in Schistosoma mansoni-induced liver fibrosis and oxidative stress in mice model.

ABSTRACT: Schistosomiasis, a neglected tropical disease caused by parasitic trematodes of the genus Schistosoma, affects over 200 million individuals worldwide. Infection with Schistosoma mansoni remains a major public health challenge, leading to pathological conditions such as liver fibrosis, hepatosplenomegaly, and portal hypertension. The pathology of schistosomiasis is predominantly driven by the retention of parasite eggs within the liver, which induces granuloma formation and periportal fibrosis, culminating in significant hepatic injury. Granulomatous responses cause the infiltration of phagocytes and lymphocytes that secrete pro-inflammatory cytokines, subsequently activating hepatic stellate cells (HSCs). Activated HSCs promote excessive extracellular matrix deposition, driving fibrotic pr

SUBMITTER: Liang TR 

PROVIDER: S-EPMC12716769 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature