Depression and weight loss trajectories during an integrated behavioral intervention: Within-treatment analysis of the RAINBOW trial.

ABSTRACT:

Introduction

Depression and obesity are two of the most common chronic conditions among US adults. The Research Aimed at Improving Both Mood and Weight (RAINBOW) study was the first randomized clinical trial to demonstrate the effectiveness of an integrated behavioral treatment for depression and obesity. We aimed to characterize the trajectories of both depression symptoms and weight loss during the RAINBOW intervention.

Methods

Participants (N = 201) randomly assigned to the RAINBOW treatment arm who provided serial data on depression symptoms (via the 9-item Patient Health Questionnaire [PHQ9]) and self-measured weight were included. Group-Based Multi-Trajectory Modeling is a statistical technique that identifies participants who follow similar trajectories of multiple ou

SUBMITTER: Osweiler BW 

PROVIDER: S-EPMC12716787 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature