Sucrose or glucose compared to breast milk for pain control in preterm infants: a systematic review and meta-analysis.

ABSTRACT: The aim of this systematic review/meta-analysis of randomized clinical trials (RCTs) was to determine the efficacy of sucrose or glucose (SG) in preterm infants requiring heel lancing and venipuncture compared to breast milk or expressed breast milk (BM/EBM) for pain control and crying duration. Six RCTs (525 infants) comparing sucrose (24%) or glucose (30%, 10%, 25%) with BM/EBM were included. There was no difference between the alternatives in pain reduction at 30 s post-procedure measured with the Premature Infant Pain Profile (PIPP/PIPP-R) scores (MD -0.95, 95% CI -2.43; 0.54, Low certainty evidence). SG reduced the crying duration (MD -6.88, 95%CI -11.42; -2.34, Moderate certainty evidence). There were no differences between SG and BM/EBM in heart rate change or adverse events. In con

SUBMITTER: Shahid S 

PROVIDER: S-EPMC12716988 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature