An improvement project standardizing low prophylactic platelet transfusion dosing for infants.

ABSTRACT:

Background

Platelet transfusions are frequently given to preterm infants to prevent bleeding, but randomized trials demonstrated harmful effects from current practices.

Problem

Many platelet transfusions were administered in 15-20 mL/kg doses.

Methods

We sought to decrease platelet exposure among neonates by standardizing 10 mL/kg transfusions for non-bleeding thrombocytopenic infants in a level IV NICU.

Interventions

We created evidence-based platelet dosing guidelines and changed practices in 3 plan-do-study-act cycles focused on education, reinforcement and electronic clinical decision support.

Results

We reviewed 240 transfusions over 3 years. The percentage of 10 mL/kg transfusions improved from 17.6% to 100%, without increasing major bleeding and r

SUBMITTER: Coletti K 

PROVIDER: S-EPMC12716995 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature