Early parenteral lipid intake supports cerebellar neurometabolism at term-age in preterm infants.

ABSTRACT:

Objectives

The impact of crucial early parenteral nutrition on neurometabolism of the preterm brain remains unclear. This study characterizes the relationship of parenteral lipid and caloric intake with cerebellar neurometabolites.

Methods

Very premature infants [born ≤32-week gestational age (GA)] in a prospective observational cohort study underwent a proton magnetic resonance spectroscopy (¹H-MRS) acquisition from a cerebellar voxel at term-age. Parenteral lipid and caloric intake (g/kg/d or kcal/kg/d) in the first 4 weeks of life were calculated by chart review.

Results

48 preterm infants born at 28.3 ± 2.4 weeks GA underwent ¹H-MRS at 38.9 ± 1.9 weeks postmenstrual age. Cerebellar N-acetylaspartate [NAA] positively correlated with 4-week par

SUBMITTER: Basu SK 

PROVIDER: S-EPMC12717006 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature