Oat protein nanofibril-iron hybrids offer a stable, high-absorption iron delivery platform for iron fortification.

ABSTRACT: Iron deficiency and anaemia affect two billion people globally. Iron fortification can help to treat anaemia, but most current fortificants are limited by low absorption and/or poor sensory properties. Here we introduce oat protein nanofibrils (OatNF) carrying ultrasmall iron nanoparticles that are engineered to carry iron in ferrous or ferric form. In a prospective cross-over stable-isotope absorption trial in young iron-deficient women (n = 52), OatNF reduced with sodium ascorbate carried mainly ferrous iron and showed high fractional absorption with water and with polyphenol-rich food, showing 1.76- and 1.65-fold higher absorption, respectively, compared with ferrous sulfate. When sodium hydroxide was used as the reducing agent, OatNF carried mainly ferric iron, which was also well abso

SUBMITTER: Zhou J 

PROVIDER: S-EPMC12717008 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature