Integrated multi-omics analysis of renal metabolism in domestic cats with spontaneous chronic kidney disease.

ABSTRACT: Chronic kidney disease (CKD) is the leading cause of mortality in aged cats. After injury, feline kidneys undergo extensive metabolic reprogramming, but a comprehensive evaluation is lacking. Here we show a multi-omics study including serum metabolomics from 14 healthy control, 15 early stages, 6 late stages CKD cats, and renal cortical and medullary tissue RNA sequencing and proteomics. The analysis reveals a spatiotemporal pattern of gene and protein expression changes. In the early stages, there are 6 differentially expressed genes in the cortex, while nearly 2000 in the medulla. The number in the cortex increases to more than 4000 in late stages. The study provides evidence of deranged bioenergetics in CKD: circulating fatty acids and acylcarnitines accumulate, while genes and proteins

SUBMITTER: Li Q 

PROVIDER: S-EPMC12717052 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature