The effect of hepatic steatosis index on prediabetes: A large-scale retrospective cohort study.

ABSTRACT: The Hepatic Steatosis Index (HSI) is a well-established metric for evaluating hepatic fat accumulation. Although prior studies have examined the effect of HSI on diabetes, its association with prediabetes remains incompletely delineated. This study aims to elucidate the effect of HSI on prediabetes within a Chinese population. We conducted a multicenter cohort analysis involving 75,750 baseline normoglycemic adults from the Rich Healthcare Group in China. To assess the effect of HSI on prediabetes, this study employed Cox proportional hazards regression, restricted cubic spline models, subgroups, and sensitivity analyses. Multivariable-adjusted models identified HSI as an independent predictor of prediabetes (HR: 1.06, 95% CI: 1.04-1.07 for females, HR: 1.04, 95% CI: 1.03-1.05 for males).

SUBMITTER: Huang X 

PROVIDER: S-EPMC12717076 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature