PRDM1-driven SLC30A9 overexpression contributes to the malignant phenotype of cervical cancer cells via promoting mitochondrial hyperfunction.

ABSTRACT: Mitochondrial hyperfunction is important for cervical cancer progression. Solute carrier family 30 member 9 (SLC30A9) is a member of the solute carrier family 30, specifically a zinc transporter that plays a critical role in mitochondrial zinc homeostasis and maintaining mitochondrial function. We investigated the expression, function, and underlying mechanisms of SLC30A9 in the context of cervical cancer. Single-cell RNA sequencing analysis revealed a marked overexpression of SLC30A9 within the malignant epithelial cell population of cervical squamous cell carcinoma. This elevated SLC30A9 expression was further corroborated in clinical specimens from local patients and across various established and primary cervical cancer cells. SLC30A9 shRNA or knockout (via CRISPR/Cas9 method) signific

SUBMITTER: Wang H 

PROVIDER: S-EPMC12717079 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature