The neural correlates of cognitive training-induced gains in aging: a meta-analysis of neuroimaging studies.

ABSTRACT: Cognitive training is a promising non-pharmacological approach to mitigate age-related cognitive decline, yet the underlying neural mechanisms remain unclear. We conducted a meta-analysis of 24 neuroimaging studies comparing cognitive training with control conditions in older adults. Outcomes included changes in cognitive function and task-related brain activation. Moderator and mediation analyses were conducted to examine the influence of participant characteristics, training parameters, and brain-behavior relationships. Cognitive training yielded moderate improvements in cognitive function (Hedges' g = 0.38) and increased activation in the left inferior frontal gyrus (LIFG) and bilateral precuneus. Age was a significant moderator of training efficacy, while training type and baseline cog

SUBMITTER: Li G 

PROVIDER: S-EPMC12717087 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature