Algorithm-based assessment of T-cell dysfunction and exclusion to forecast ICB sensitivity in pediatric brain ependymoma.

ABSTRACT:

Background

Pediatric brain ependymomas are brain tumors difficult to cure despite the advancements in surgery and radiotherapy. Immunotherapies, specifically immune checkpoint blockades (ICB), are traditionally recognized to have a limited efficacy against cold microenvironment as the ones of ependymomas. By employing the Tumor Immune Dysfunction and Exclusion (TIDE) scoring system, this study tries to predict the responsiveness to ICB across molecular subgroups, recurrent/primary presentation and hot vs. cold subtypes.

Methods

Four GEO datasets from NCBI public library were selected for this study. In total, 150 RNA-bulk sequences of pediatric ependymomas were analyzed (PF-A = 125, ZFTA-RELA = 23, YAP1 = 2). The TIDE algorithm was applied to quantify cytotoxic T-cell infilt

SUBMITTER: Palermo M 

PROVIDER: S-EPMC12717181 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature