Neuronal and Glial Biomarkers in Urine of Athletes with Different Risks of Head Trauma to Monitor Sports-Related Concussions.

ABSTRACT: Neuronal and glial biomarkers like glial fibrillary acidic protein (GFAP), ubiquitin C-terminal hydrolase-L1 (UCH-L1), tau protein, and neurofilament light chain (NfL) in serum are reported to be beneficial in detecting sports-related concussions (SRC) or intracranial trauma sequelae. However, routine blood measurements are invasive, and a non-invasive approach using urine could be advantageous. This prospective study analyzed urine samples from athletes with varying head trauma risks: high-risk (boxing), moderate-risk (American football, soccer), and low-risk (endurance sports). Samples were collected before (pre) and 48-72 h after (post) competition. Consecutive matches per athlete were sampled. Biomarker concentrations were adjusted for urine dilution using the creatinine ratio (CR). St

SUBMITTER: Kohlhase K 

PROVIDER: S-EPMC12717207 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature