Pressurized intraperitoneal aerosol chemotherapy enhances cisplatin efficacy in colorectal cancer organoids.

ABSTRACT: Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is an emerging method that delivers chemotherapeutic agents as aerosols directly into the peritoneal cavity to overcome poor tissue penetration. Although early clinical outcomes are promising, challenges remain, such as variable patient responses and the lack of appropriate preclinical models. In this study, we investigated the efficacy of PIPAC combined with three cytotoxic agents (Cisplatin, Oxaliplatin, and Paclitaxel) using patient-derived colorectal cancer organoid models. Our results demonstrates that PIPAC, especially when combined with Cisplatin, significantly enhances the cytotoxicity against colorectal cancer organoids and modulates key cancer-related pathways. Transcriptomic analysis revealed significant alterations in gen

SUBMITTER: Kim SC 

PROVIDER: S-EPMC12717258 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature