Redox properties of quercetin iron Ii complex with enhanced antioxidant and antiviral activities.

ABSTRACT: Quercetin is a naturally occurring flavonoid widely recognized for its potent antioxidant, anti-inflammatory, and anticancer effects. However, its clinical application is limited by low water solubility and poor bioavailability. In this study, the complexation of quercetin with iron (II) ions was systematically investigated through electrochemical, spectroscopic, biological, and computational techniques to improve its physicochemical and pharmacological performance. Cyclic voltammetry revealed that quercetin undergoes irreversible oxidation due to semiquinone and para-quinonemethide formation, while Fe(II) exhibited quasi-reversible redox behavior, which became less reversible upon complexation, suggesting altered electron transfer kinetics. The stability constant (log βMX = 3.29) and the

SUBMITTER: Hameed SEA 

PROVIDER: S-EPMC12717270 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature