Atrophy progression in frontotemporal lobar degeneration-TDP-C with primary progressive aphasia.

ABSTRACT: Clinicopathologic correlations in neurodegenerative diseases have led to novel insights on the neurobiology of selective vulnerability and the anatomy of cognitive networks. The neuropathologic entity of frontotemporal lobar degeneration with abnormal precipitates of the transactive response DNA binding protein TDP-43 (FTLD-TDP) of type C (TDP-C) is one of the most distinctive examples. TDP-C invariably starts with neurodegeneration (atrophy) confined to the temporopolar regions (TPR). The process is usually asymmetric, causing behavioral abnormalities and associative agnosia when predominantly right-sided, semantic Primary Progressive Aphasia (PPA) when left-sided, and semantic dementia when bilateral. In this study, we investigated the relationship between atrophy progression and the pro

SUBMITTER: Barbieri E 

PROVIDER: S-EPMC12717277 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature