Noncontact Fiber Optic Probe for Clinical Applications of Raman Spectroscopy.

ABSTRACT: Clinical applications of Raman spectroscopy (RS) typically rely on fiber optic probes that directly interface with the tissue site. These devices are designed with small diameters, enabling them to navigate narrow body cavities and seamlessly integrate into routine medical instruments. However, the performance of conventional RS fiber probes suffers during noncontact operation due to decreased collection efficiency and a larger laser spot size that restricts spatial precision. To address these limitations, a novel RS probe design is presented here that can efficiently collect both fingerprint (FP) and high-wavenumber (HW) regions of the Raman spectrum at an offset from the target tissue using a miniature lens at the probe tip. The development process began with stochastic light propagation

SUBMITTER: Fitzgerald S 

PROVIDER: S-EPMC12717308 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature